Bone Disorders Essay Example | Topics and Well Written Essays - 1250 words

Bone Disorders - Essay ExampleBone problems are of different kinds. They may include osteoporosis caused by low density of fancy up and which makes grind away weak and susceptible to breakage, osteogenesis imperfect which increases the brittleness of bones, and Pagets bones disease which makes bones weaker. In addition to these bone disorders, bones may also work up a range of infections and cancers.There can be many reasons for the development of bone disorders. Some major causes of bone disorders include genetic factors, misfortunate nutrition, and poor rate of rebuilding and growth of bones. The most important modulators of the process by which bones form are hormones. Optimal development and maintenance of bones depends upon parathyroid gland hormone, estrogen, and testosterone. Of these, the most direct impact on the cells of bone is made by estrogen which interacts with specific receptors or proteins on the surface of osteoclasts and osteoblasts (Zallone, 2006). Bones maint ain their peculiarity and integrity through a process of continuous renewal known as remodeling. Accelerated bone remodeling may cause a range of bone disorders that include but are not limited to familial expansile osteolysis (FEO), juvenile Pagets disease (JPD), Pagets disease of bone (PDB), early-onset Pagets disease of bone (EOPDB), and expansile penurious hyperphosphatasia (ESH) (Beyens and Van Hul, 2007). Many studies have concluded that the main cells responsible for causing disease in these bone disorders are bone-resorbing osteoclasts.Connective tissues are unlike the parenchymal variety meat in that their form and function reflects the extracellular matrices of the matter they are made up of. These different compositions of matrices lend unique appearance and mechanical properties to cartilage, bone, and dense fibrous connective tissue (Teitelbaum and Bullough, 1979). Dense fibrous connective tissue is made up of collagen in the form of well-oriented collagen bundles w hose main